A Brief History of Pharmacogenetics:

525 BC – Pythagoras noted that eating fava beans resulted in adverse reactions in some but not in others

(centuries later a G6PD deficiency was proven to be the culprit)

1906 – English physiologist proposes that genetic variations might account for differing drug responses

1932 – the first pharmacogenetics study

1950 Term “pharmacogenetics” used to describe phenomena of genes causing different responses to drugs

1962 – First text book published “Pharmacogenetics – Heredity and the Response to Drugs”

2003 – Human Genome Project Completed

2005 – FDA approves pharmacogenetics test.

 

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