A Brief History of Pharmacogenetics:
525 BC – Pythagoras noted that eating fava beans resulted in adverse reactions in some but not in others
(centuries later a G6PD deficiency was proven to be the culprit)
1906 – English physiologist proposes that genetic variations might account for differing drug responses
1932 – the first pharmacogenetics study
1950 Term “pharmacogenetics” used to describe phenomena of genes causing different responses to drugs
1962 – First text book published “Pharmacogenetics – Heredity and the Response to Drugs”
2003 – Human Genome Project Completed
2005 – FDA approves pharmacogenetics test.
