What is DNA?

     DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus

(where it is called nuclear DNA), but a small amount of DNA can also be found

in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Mitochondria are structures within cells that convert the energy from food into

a form that cells can use. The information in DNA is stored as a code made up

of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T).

Human DNA consists of about 3 billion bases, and more than 99 percent of those

bases are the same in all people. The order, or sequence, of these bases

determines the information available for building and maintaining an organism,

similar to the way in which letters of the alphabet appear in a certain order to form

words and sentences.

 

     DNA bases pair up with each other, A with T and C with G, to form units

called base pairs. Each base is also attached to a sugar molecule and a phosphate

molecule. Together, a base, sugar, and phosphate are called a nucleotide.

Nucleotides are arranged in two long strands that form a spiral called a double

helix. The structureof the double helix is somewhat like a ladder, with the base pairs

forming the ladder’s rungs and the sugar and phosphate molecules forming the vertical sidepieces of the ladder.  An important property of DNA is that it can replicate, or make copies of itself. Each strand of DNA in the double helix can serve as a pattern for duplicating the sequence of bases. This is critical when cells divide because each new cell needs to have an exact copy of the DNA present in the old cell.

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